Pesquisa | Secretaria de Estado da Saúde

1.

Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

Saunders, Kevin O; Counts, James; Thakur, Bhishem; Stalls, Victoria; Edwards, Robert; Manne, Kartik; Lu, Xiaozhi; Mansouri, Katayoun; Chen, Yue; Parks, Rob; Barr, Maggie; Sutherland, Laura; Bal, Joena; Havill, Nicholas; Chen, Haiyan; Machiele, Emily; Jamieson, Nolan; Hora, Bhavna; Kopp, Megan; Janowska, Katarzyna; Anasti, Kara; Jiang, Chuancang; Van Itallie, Elizabeth; Venkatayogi, Sravani; Eaton, Amanda; Henderson, Rory; Barbosa, Christopher; Alam, S Munir; Santra, Sampa; Weissman, Drew; Moody, M Anthony; Cain, Derek W; Tam, Ying K; Lewis, Mark; Williams, Wilton B; Wiehe, Kevin; Montefiori, David C; Acharya, Priyamvada; Haynes, Barton F.

Cell ; 187(1): 79-94.e24, 2024 01 04.

Artigo Inglês | MEDLINE | ID: mdl-38181743

2.

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; Lu, Xiaozhi; Parks, Robert; Sutherland, Laura L; Oguin, Thomas H; McDanal, Charlene; Perez, Lautaro G; Mansouri, Katayoun; Gobeil, Sophie M C; Janowska, Katarzyna; Stalls, Victoria; Kopp, Megan; Cai, Fangping; Lee, Esther; Foulger, Andrew; Hernandez, Giovanna E; Sanzone, Aja; Tilahun, Kedamawit; Jiang, Chuancang; Tse, Longping V; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Cronin, Kenneth; Gee-Lai, Victoria; Deyton, Margaret; Barr, Maggie; Von Holle, Tarra; Macintyre, Andrew N; Stover, Erica; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Scobey, Trevor D; Rountree, Wes; Wang, Yunfei; Moody, M Anthony; Cain, Derek W; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Schmidt, Aaron G; Teng, I-Ting.

Cell ; 184(16): 4203-4219.e32, 2021 08 05.

Artigo Inglês | MEDLINE | ID: mdl-34242577

3.

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M.

Cell ; 184(11): 2955-2972.e25, 2021 05 27.

Artigo Inglês | MEDLINE | ID: mdl-34019795

4.

RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.

Bradley, Todd; Peppa, Dimitra; Pedroza-Pacheco, Isabela; Li, Dapeng; Cain, Derek W; Henao, Ricardo; Venkat, Vaishnavi; Hora, Bhavna; Chen, Yue; Vandergrift, Nathan A; Overman, R Glenn; Edwards, R Whitney; Woods, Chris W; Tomaras, Georgia D; Ferrari, Guido; Ginsburg, Geoffrey S; Connors, Mark; Cohen, Myron S; Moody, M Anthony; Borrow, Persephone; Haynes, Barton F.

Cell ; 175(2): 387-399.e17, 2018 10 04.

Artigo Inglês | MEDLINE | ID: mdl-30270043

5.

Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth.

Roskin, Krishna M; Jackson, Katherine J L; Lee, Ji-Yeun; Hoh, Ramona A; Joshi, Shilpa A; Hwang, Kwan-Ki; Bonsignori, Mattia; Pedroza-Pacheco, Isabela; Liao, Hua-Xin; Moody, M Anthony; Fire, Andrew Z; Borrow, Persephone; Haynes, Barton F; Boyd, Scott D.

Nat Immunol ; 21(2): 199-209, 2020 02.

Artigo Inglês | MEDLINE | ID: mdl-31959979

6.

Viral receptor-binding site antibodies with diverse germline origins.

Schmidt, Aaron G; Therkelsen, Matthew D; Stewart, Shaun; Kepler, Thomas B; Liao, Hua-Xin; Moody, M Anthony; Haynes, Barton F; Harrison, Stephen C.

Cell ; 161(5): 1026-1034, 2015 May 21.

Artigo Inglês | MEDLINE | ID: mdl-25959776

7.

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Gao, Feng; Bonsignori, Mattia; Liao, Hua-Xin; Kumar, Amit; Xia, Shi-Mao; Lu, Xiaozhi; Cai, Fangping; Hwang, Kwan-Ki; Song, Hongshuo; Zhou, Tongqing; Lynch, Rebecca M; Alam, S Munir; Moody, M Anthony; Ferrari, Guido; Berrong, Mark; Kelsoe, Garnett; Shaw, George M; Hahn, Beatrice H; Montefiori, David C; Kamanga, Gift; Cohen, Myron S; Hraber, Peter; Kwong, Peter D; Korber, Bette T; Mascola, John R; Kepler, Thomas B; Haynes, Barton F.

Cell ; 158(3): 481-91, 2014 Jul 31.

Artigo Inglês | MEDLINE | ID: mdl-25065977

8.

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.

Krebs, Shelly J; Kwon, Young D; Schramm, Chaim A; Law, William H; Donofrio, Gina; Zhou, Kenneth H; Gift, Syna; Dussupt, Vincent; Georgiev, Ivelin S; Schätzle, Sebastian; McDaniel, Jonathan R; Lai, Yen-Ting; Sastry, Mallika; Zhang, Baoshan; Jarosinski, Marissa C; Ransier, Amy; Chenine, Agnes L; Asokan, Mangaiarkarasi; Bailer, Robert T; Bose, Meera; Cagigi, Alberto; Cale, Evan M; Chuang, Gwo-Yu; Darko, Samuel; Driscoll, Jefferson I; Druz, Aliaksandr; Gorman, Jason; Laboune, Farida; Louder, Mark K; McKee, Krisha; Mendez, Letzibeth; Moody, M Anthony; O'Sullivan, Anne Marie; Owen, Christopher; Peng, Dongjun; Rawi, Reda; Sanders-Buell, Eric; Shen, Chen-Hsiang; Shiakolas, Andrea R; Stephens, Tyler; Tsybovsky, Yaroslav; Tucker, Courtney; Verardi, Raffaello; Wang, Keyun; Zhou, Jing; Zhou, Tongqing; Georgiou, George; Alam, S Munir; Haynes, Barton F; Rolland, Morgane.

Immunity ; 50(3): 677-691.e13, 2019 03 19.

Artigo Inglês | MEDLINE | ID: mdl-30876875

9.

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Bonsignori, Mattia; Scott, Eric; Wiehe, Kevin; Easterhoff, David; Alam, S Munir; Hwang, Kwan-Ki; Cooper, Melissa; Xia, Shi-Mao; Zhang, Ruijun; Montefiori, David C; Henderson, Rory; Nie, Xiaoyan; Kelsoe, Garnett; Moody, M Anthony; Chen, Xuejun; Joyce, M Gordon; Kwong, Peter D; Connors, Mark; Mascola, John R; McGuire, Andrew T; Stamatatos, Leonidas; Medina-Ramírez, Max; Sanders, Rogier W; Saunders, Kevin O; Kepler, Thomas B; Haynes, Barton F.

Immunity ; 49(6): 1162-1174.e8, 2018 12 18.

Artigo Inglês | MEDLINE | ID: mdl-30552024

10.

Transient inhibition of lysosomal functions potentiates nucleic acid vaccines.

Wang, Chunxi; Karlsson, Amelia; Oguin, Thomas H; Macintyre, Andrew N; Sempowski, Gregory D; McCarthy, Kevin R; Wang, Yifei; Moody, M Anthony; Yuan, Fan.

Proc Natl Acad Sci U S A ; 120(44): e2306465120, 2023 Oct 31.

Artigo Inglês | MEDLINE | ID: mdl-37871214

11.

Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates.

McCarthy, Kevin R; Von Holle, Tarra A; Sutherland, Laura L; Oguin, Thomas H; Sempowski, Gregory D; Harrison, Stephen C; Moody, M Anthony.

Proc Natl Acad Sci U S A ; 118(23)2021 06 08.

Artigo Inglês | MEDLINE | ID: mdl-34074774

12.

Lessons From COVID-19 for Pandemic Preparedness: Proceedings From a Multistakeholder Think Tank.

Narayanasamy, Shanti; Curtis, Lesley H; Hernandez, Adrian F; Woods, Christopher W; Moody, M Anthony; Sulkowski, Mark; Turbett, Sarah E; Baden, Lindsey R; Gulick, Roy M; Pau, Alice K; Adam, Stacey J; Marks, Peter; Stockbridge, Norman L; Dobbins, John R; Krofah, Esther; Leav, Brett; Pang, Phil; Roessig, Lothar; Vedin, Ola; Waldstreicher, Joanne; Berman, Stacey Cromer; Cremisi, Henry; Schofield, Lesley; Gandhi, Rajesh T; Naggie, Susanna.

Clin Infect Dis ; 77(12): 1635-1643, 2023 Dec 15.

Artigo Inglês | MEDLINE | ID: mdl-37435958

13.

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.

Cai, Fangping; Chen, Wei-Hung; Wu, Weimin; Jones, Julia A; Choe, Misook; Gohain, Neelakshi; Shen, Xiaoying; LaBranche, Celia; Eaton, Amanda; Sutherland, Laura; Lee, Esther M; Hernandez, Giovanna E; Wu, Nelson R; Scearce, Richard; Seaman, Michael S; Moody, M Anthony; Santra, Sampa; Wiehe, Kevin; Tomaras, Georgia D; Wagh, Kshitij; Korber, Bette; Bonsignori, Mattia; Montefiori, David C; Haynes, Barton F; de Val, Natalia; Joyce, M Gordon; Saunders, Kevin O.

PLoS Pathog ; 17(6): e1009624, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-34086838

14.

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.

Wiehe, Kevin; Easterhoff, David; Luo, Kan; Nicely, Nathan I; Bradley, Todd; Jaeger, Frederick H; Dennison, S Moses; Zhang, Ruijun; Lloyd, Krissey E; Stolarchuk, Christina; Parks, Robert; Sutherland, Laura L; Scearce, Richard M; Morris, Lynn; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Rerks-Ngarm, Supachai; Sinangil, Faruk; Phogat, Sanjay; Michael, Nelson L; Kim, Jerome H; Kelsoe, Garnett; Montefiori, David C; Tomaras, Georgia D; Bonsignori, Mattia; Santra, Sampa; Kepler, Thomas B; Alam, S Munir; Moody, M Anthony; Liao, Hua-Xin; Haynes, Barton F.

Immunity ; 41(6): 909-18, 2014 Dec 18.

Artigo Inglês | MEDLINE | ID: mdl-25526306

15.

Frequent Development of Broadly Neutralizing Antibodies in Early Life in a Large Cohort of Children With Human Immunodeficiency Virus.

Lucier, Amanda; Fong, Youyi; Li, Shuk Hang; Dennis, Maria; Eudailey, Joshua; Nelson, Ashley; Saunders, Kevin; Cunningham, Coleen K; McFarland, Elizabeth; McKinney, Ross; Moody, M Anthony; LaBranche, Celia; Montefiori, David; Permar, Sallie R; Fouda, Genevieve G.

J Infect Dis ; 225(10): 1731-1740, 2022 05 16.

Artigo Inglês | MEDLINE | ID: mdl-34962990

16.

Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.

Hurst, Jillian H; McCumber, Alexander W; Aquino, Jhoanna N; Rodriguez, Javier; Heston, Sarah M; Lugo, Debra J; Rotta, Alexandre T; Turner, Nicholas A; Pfeiffer, Trevor S; Gurley, Thaddeus C; Moody, M Anthony; Denny, Thomas N; Rawls, John F; Clark, James S; Woods, Christopher W; Kelly, Matthew S.

Clin Infect Dis ; 75(1): e928-e937, 2022 08 24.

Artigo Inglês | MEDLINE | ID: mdl-35247047

17.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao, Hua-Xin; Bonsignori, Mattia; Alam, S Munir; McLellan, Jason S; Tomaras, Georgia D; Moody, M Anthony; Kozink, Daniel M; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J; Montefiori, David C; Ferrari, Guido; Pollara, Justin; Rao, Mangala; Peachman, Kristina K; Santra, Sampa; Letvin, Norman L; Karasavvas, Nicos; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Wiehe, Kevin; Nicely, Nathan I; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Tartaglia, James; Sinangil, Faruk; Kim, Jerome H; Michael, Nelson L; Kepler, Thomas B; Kwong, Peter D; Mascola, John R; Nabel, Gary J; Pinter, Abraham; Zolla-Pazner, Susan; Haynes, Barton F.

Immunity ; 38(1): 176-86, 2013 Jan 24.

Artigo Inglês | MEDLINE | ID: mdl-23313589

18.

Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.

Hurst, Jillian H; Heston, Sarah M; Chambers, Hailey N; Cunningham, Hannah M; Price, Meghan J; Suarez, Lilianna; Crew, Carter G; Bose, Shree; Aquino, Jhoanna N; Carr, Stuart T; Griffin, S Michelle; Smith, Stephanie H; Jenkins, Kirsten; Pfeiffer, Trevor S; Rodriguez, Javier; DeMarco, C Todd; De Naeyer, Nicole A; Gurley, Thaddeus C; Louzao, Raul; Zhao, Congwen; Cunningham, Coleen K; Steinbach, William J; Denny, Thomas N; Lugo, Debra J; Moody, M Anthony; Permar, Sallie R; Rotta, Alexandre T; Turner, Nicholas A; Walter, Emmanuel B; Woods, Christopher W; Kelly, Matthew S.

Clin Infect Dis ; 73(9): e2875-e2882, 2021 11 02.

Artigo Inglês | MEDLINE | ID: mdl-33141180

19.

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.

Easterhoff, David; Pollara, Justin; Luo, Kan; Tolbert, William D; Young, Brianna; Mielke, Dieter; Jha, Shalini; O'Connell, Robert J; Vasan, Sandhya; Kim, Jerome; Michael, Nelson L; Excler, Jean-Louis; Robb, Merlin L; Rerks-Ngarm, Supachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Nitayaphan, Sorachai; Sinangil, Faruk; Tartaglia, James; Phogat, Sanjay; Kepler, Thomas B; Alam, S Munir; Wiehe, Kevin; Saunders, Kevin O; Montefiori, David C; Tomaras, Georgia D; Moody, M Anthony; Pazgier, Marzena; Haynes, Barton F; Ferrari, Guido.

J Virol ; 94(4)2020 01 31.

Artigo Inglês | MEDLINE | ID: mdl-31776278

20.

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody.

Raymond, Donald D; Bajic, Goran; Ferdman, Jack; Suphaphiphat, Pirada; Settembre, Ethan C; Moody, M Anthony; Schmidt, Aaron G; Harrison, Stephen C.

Proc Natl Acad Sci U S A ; 115(1): 168-173, 2018 01 02.

Artigo Inglês | MEDLINE | ID: mdl-29255041

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